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Distribution of lymph node metastases in patients with ovarian cancer

Leszek Jarosław Gmyrek1, Joanna Jońska-Gmyrek2, Mariusz Bidziński1, Piotr Sobiczewski1, Anna Dańska-Bidzińska1

Affiliacja i adres do korespondencji
CURR. GYNECOL. ONCOL. 2010, 8 (1), p. 27-33
Streszczenie

Background: Ovarian cancer disseminates by lymphatic vessels much more frequently than any other gynecological malignancy. Assessment of regional lymph nodes is an integral part of diagnostic work-up in ovarian cancer patients. It contributes essential information enabling correct clinical staging and, by the same token, definition of optimal therapeutic management. Aim of paper: Determination of distribution of lymphatic metastases in ovarian cancer patients. Material and method: Retrospective analysis of 211 consecutive patients with ovarian cancer, treated at the Institute of Oncology, Warsaw, Poland, since 1998 thru 2006. All patients underwent surgical treatment, according to currently valid protocol, including pelvic and periaortal lymphadenectomy, followed by complementary chemotherapy. Analysis encompassed location of lymph node metastases and correlation thereof with key clinical-pathological variables, including clinical stage, grade of differentiation and histological tumor type. Results: Ovarian cancer patients diagnosed with FIGO stage I and II had a similar prevalence of pelvic and periaortal lymph node metastases. In advanced ovarian cancer cases (FIGO stage III and IV), periaortal lymph nodes were invaded more often than pelvic ones. Conclusion: Lymph node metastases are frequent in ovarian cancer patients. Their incidence depends on clinical stage (acc. to FIGO classification), as well as tumor grade and type.

Słowa kluczowe
ovarian cancer, lymph nodes, distribution, incidence, staging