TNF-a affecting the majority of biologically active cells, plays a pivotal role in the antineoplasmatic answer. The soluble forms of TNF-a (sTNF-R) have the possibility of their neutralization. The intercellular adhesion molecules (ICAM-1) in ovarian cancer come from neoplasmatic cells surface and indicate the troubles of interaction between them and immunocompetent cells. The aim of the study was the evaluation of the sTNF-R and sICAM-1 serum concentration in ovarian cancer patients, and the answer to the question, if they can have any prognostic value. In the first group were the patients in I/II clinical stage of ovarian cancer. In the second group were ovarian cancer patients in III/IV clinical stage, according to FIGO, in the third group were the healthy women. The analysis of the sTNF-R serum concentration has shown the difference only between the group II and III. The sICAM-1 concentrations were statistically higher in the I and II groups, compared to the III group. The significant differences of the sICAM-1 concentration were shown between the group I and II. The correlation between the sICAM-1 and sTNF-R1 and sTNF-R2 in the II group was observed, and also the dependency between sTNF-R1 and sTNF-R2 was noticed. The results of the study suggest, that the high sTNF-R2 and sICAM-1 serum concentration are associated with progression of the disease.